Meredith Grey, M.D., F.A.C.S. is a fictional and titular character from the medical drama television series Grey's Anatomy, which airs on the American Broadcasting Company (ABC) in the United States. The character was created by series producer Shonda Rhimes, and is portrayed by actress Ellen Pompeo. She made her first appearance in the pilot episode, "A Hard Day's Night", which was broadcast on March 27, 2005. She made her last appearance (as a series regular) in the seventh episode of season 19, "I'll Follow the Sun" which was broadcast on February 23, 2023. She will continue to do the voiceover at the beginning and end of each episode. Meredith appears in the spin-off series Station 19 as a recurring character.

Meredith is the series' protagonist, and was introduced as a surgical intern at the fictional Seattle Grace Hospital (later Seattle Grace-Mercy West Hospital, and afterwards Grey+Sloan Memorial), eventually obtaining the position of a surgical resident, and later the position of an attending, and in 2016, attaining the Chief of General Surgery position. As the daughter of world-renowned surgeon Ellis Grey, Meredith struggles with the everyday life of being in a competitive profession, maintaining the relationship with her one-night stand and eventual husband, Derek Shepherd (McDreamy), her motherhood, and her friendships with her colleagues.

Meredith is the narrator of the show and serves as the focal point for most episodes, although the audience receives perspectives from other characters as well. Pompeo's connection with Patrick Dempsey (Derek Shepherd) is acclaimed as a high point of the series. Rhimes has characterized Meredith as not believing in good or bad, but instead doing what she thinks is right. Grey has been positively received by television critics, with Alessandra Stanley of The New York Times referring to her as "the heroine of Grey's Anatomy".

Pompeo's performance has been well received throughout the show and the character has gained widespread popularity worldwide. Pompeo has been nominated for multiple awards for her portrayal of the character in the long running ABC medical drama including Satellite Award for Best Actress and multiple nominations at the People's Choice Awards for Best Actress winning at 39th People's Choice Awards in 2013 and again in 2015 at 41st People's Choice Awards, Pompeo has also received a Best Performance by an Actress in a Drama Series nomination at the 64th Golden Globe Awards.